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This missionary couple must have felt like they were going to face the same discouraging results as Isaiah when they went to the hill peoples of India’s Tamil Nadu. How do missionaries keep going when people don’t listen to them any more than the Israelites did to Isaiah? Again, it all boils down to obedience and the call of God, no matter how hard it may seem.
Pray that God will give missionaries a willingness to never leave their calling, even when it’s difficult.